Simple item record
Title: thalassemia in children's hospital
Other Titles: How to Pactric Thalassaemia
Authors: khounthavy, phongsavath
Keywords: Thalassemia in Children's hospital
Issue Date: 27-Sep-2013
Abstract: Thalassemia (British English: thalassaemia) are forms of inherited autosomal recessive blood disorders that originated in the Mediterranean region. In thalassemia, the disease is caused by the weakening and destruction of red blood cells. Thalassemia is caused by variant or missing genes that affect how the body makes hemoglobin. Hemoglobin is the protein in red blood cells that carries oxygen. People with thalassemia make less hemoglobin and fewer circulating red blood cells than normal, which results in mild or severe anemia. Thalassemia will be present as microcytic anemia which may be differentiated from iron deficiency anemia using the mentzer index calculation. Thalassemia can cause significant complications, including iron overload, bone deformities and cardiovascular illness. However this same inherited disease of red blood cells may confer a degree of protection against malaria, which is or was prevalent in the regions where the trait is common. This selective survival advantage on carriers (known as heterozygous advantage) may be responsible for perpetuating the mutation in populations. In that respect, the various thalassemias resemble another genetic disorder affecting hemoglobin, sickle-cell disease.[1] [2]
Description: Barriers of thalassemia control in Laos – Policy of thalassemia control is not available – National guideline for thalassemia screening and treatment is not unified – Lacking of human resources such as hematologist , laboratory technicians, etc – Lacking of medical equipment in the field of hematology – Iron chelators are not included in the essential drug list – Thalassemia treatment unit is not available
URI: http://hdl.handle.net/11267/1818

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