Genetic Variability of Plasmodium malariae dihydropteroate synthase (dhps) in Four Asian Countries

Title
Genetic Variability of Plasmodium malariae dihydropteroate synthase (dhps) in Four Asian Countries
Authors
Tanomsing, Naowarat; Mayxay, Mayfong; Newton, Paul N.; Nosten, Francois; Dolecek, Christiane; Tran Tinh Hien; White, Nicholas J.; Day, Nicholas P. J.; Dondorp, Arjen M.; Imwong, Mallika
Keywords
DIHYDROFOLATE-REDUCTASE GENE, POINT MUTATIONS, DRUG PRESSURE, PYRIMETHAMINE, RESISTANCE, FALCIPARUM, VIVAX
Issue Date
2014
Publisher
PUBLIC LIBRARY SCIENCE
Citation
PLOS ONE; vol.9 issue 4
Abstract
The dihydropteroate synthase (dhps) genes of 44 P. malariae strains from four Asian countries were isolated. Only a limited number of polymorphisms were observed. Comparison with homologous mutations in other Plasmodium species showed that these polymorphisms are unlikely to be associated with sulfadoxine resistance.
URI
http://hdl.handle.net/11267/2205
ISSN
1932-6203
Appears in Collections:
3.University of Health Sciences > Faculty of postgraduate > Journal articles
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