Impaired clinical response in a patient with uncomplicated falciparum malaria who received poor-quality and underdosed intramuscular artemether

DC FieldValueLanguage
dc.contributor.author
Keoluangkhot, Valy
-
dc.contributor.author
Green, Michael D.
-
dc.contributor.author
Nyadong, Leonard
-
dc.contributor.author
Fernandez, Facundo M.
-
dc.contributor.author
Mayxay, Mayfong
-
dc.contributor.author
Newton, Paul N.
-
dc.date.accessioned
2014-07-21T08:41:18Z
-
dc.date.available
2014-07-21T08:41:18Z
-
dc.date.issued
2008
-
dc.identifier.citation
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE; vol.78 issue 4
-
dc.identifier.issn
0002-9637
-
dc.identifier.uri
http://hdl.handle.net/11267/2211
-
dc.description.abstract
We describe an adult with uncomplicated Plasmodium falciparum malaria who did not improve clinically despite 5 days of intramuscular artemether therapy. He was prescribed a lower dose (kg body weight) than that recommended, and a vial from the packet contained only 74% of the artemether dose as stated by the manufacturer. The combination of underdosing, poor-quality drug, and the intrinsic low bioavailability of artemether may have contributed to his poor clinical response. Analysis of the packaging and chemical nullfingerprintingnull of the artemether suggested that the drug, was genuine but was either substandard or had deteriorated after manufacture.
-
dc.language.iso
English
-
dc.publisher
AMER SOC TROP MED & HYGIENE
-
dc.subject
COUNTERFEIT
-
dc.subject
ARTESUNATE
-
dc.subject
QUININE
-
dc.subject
TRIAL
-
dc.subject
ANTIMALARIALS
-
dc.subject
RESISTANCE
-
dc.subject
DRUGS
-
dc.title
Impaired clinical response in a patient with uncomplicated falciparum malaria who received poor-quality and underdosed intramuscular artemether
-
Appears in Collections:
5.Mahosot Hospital > Journal articles
Files in This Item:

qrcode

Items in LAOSpace are protected by copyright, with all rights reserved, unless otherwise indicated.