TNP-470, A METAP2 INHIBITOR, INHIBITS PROLIFERATION BY INDUCTION OF APOPTOSIS AND ENHANCES THE ANTI-TUMOR ACTIVITY OF CHEMOTHERPEUTIC DRUGS ON CHOLANGIOCARCINOMA CELL LINES

Title
TNP-470, A METAP2 INHIBITOR, INHIBITS PROLIFERATION BY INDUCTION OF APOPTOSIS AND ENHANCES THE ANTI-TUMOR ACTIVITY OF CHEMOTHERPEUTIC DRUGS ON CHOLANGIOCARCINOMA CELL LINES
Authors
KIDOIKHAMMOUAN, Sonexai
Keywords
TNP-470, APOPTOSIS, CHEMOTHERPEUTIC DRUGS, CHOLANGIOCARCINOMA
Issue Date
2013-12
Publisher
Khon Kaen University
Citation
23p.
Abstract
TNP-470 exhibits anti-tumor activity
against human CCA cells by enhancing apoptosis through the activation of p38
pathway. In addition, supplementation of TNP-470 was also enhanced antiproliferation
of chemotherapeutic drugs by given synergistic effect on CCA cell lines.
Up to our knowledge, we suggest that TNP-470 might be a potential adjuvant agent to
enhance the effect of chemotherapeutic drugs for the treatment of CCA patients in the
future.
Description
Molecular alterations associated with CCA have been explored by using
different high-throughput techniques. Exploiting select molecular targets that are
aberrantly expressed during carcinogenesis and metastasis of CCA is one approach
being used to develop specific chemopreventive and therapeutic strategies.
Accordingly, we applied a comparative genomics approach by using the serial
analysis of gene expression (SAGE) database (http://cgap.nci.nih.gov/SAGE).
A comparison of SAGE data of tissues obtained from CCA and normal liver indicated
that several genes are up-regulated in CCA tissues. We focused on the methionine
aminopeptidase2 (MetAP2) for further investigation.
URI
http://hdl.handle.net/11267/2233
Appears in Collections:
3.University of Health Sciences > Faculty of basic sciences > Educational materials
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