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Title: TNP-470, A METAP2 INHIBITOR, INHIBITS PROLIFERATION BY INDUCTION OF APOPTOSIS AND ENHANCES THE ANTI-TUMOR ACTIVITY OF CHEMOTHERPEUTIC DRUGS ON CHOLANGIOCARCINOMA CELL LINES
Authors: KIDOIKHAMMOUAN, Sonexai
Keywords: TNP-470, APOPTOSIS, CHEMOTHERPEUTIC DRUGS
CHOLANGIOCARCINOMA
Issue Date: Dec-2013
Publisher: Khon Kaen University
Citation: 23p.
Abstract: TNP-470 exhibits anti-tumor activity against human CCA cells by enhancing apoptosis through the activation of p38 pathway. In addition, supplementation of TNP-470 was also enhanced antiproliferation of chemotherapeutic drugs by given synergistic effect on CCA cell lines. Up to our knowledge, we suggest that TNP-470 might be a potential adjuvant agent to enhance the effect of chemotherapeutic drugs for the treatment of CCA patients in the future.
Description: Molecular alterations associated with CCA have been explored by using different high-throughput techniques. Exploiting select molecular targets that are aberrantly expressed during carcinogenesis and metastasis of CCA is one approach being used to develop specific chemopreventive and therapeutic strategies. Accordingly, we applied a comparative genomics approach by using the serial analysis of gene expression (SAGE) database (http://cgap.nci.nih.gov/SAGE). A comparison of SAGE data of tissues obtained from CCA and normal liver indicated that several genes are up-regulated in CCA tissues. We focused on the methionine aminopeptidase2 (MetAP2) for further investigation.
URI: http://hdl.handle.net/11267/2233

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