TNP-470 exhibits anti-tumor activity
against human CCA cells by enhancing apoptosis through the activation of p38
pathway. In addition, supplementation of TNP-470 was also enhanced antiproliferation
of chemotherapeutic drugs by given synergistic effect on CCA cell lines.
Up to our knowledge, we suggest that TNP-470 might be a potential adjuvant agent to
enhance the effect of chemotherapeutic drugs for the treatment of CCA patients in the
Molecular alterations associated with CCA have been explored by using
different high-throughput techniques. Exploiting select molecular targets that are
aberrantly expressed during carcinogenesis and metastasis of CCA is one approach
being used to develop specific chemopreventive and therapeutic strategies.
Accordingly, we applied a comparative genomics approach by using the serial
analysis of gene expression (SAGE) database (http://cgap.nci.nih.gov/SAGE).
A comparison of SAGE data of tissues obtained from CCA and normal liver indicated
that several genes are up-regulated in CCA tissues. We focused on the methionine
aminopeptidase2 (MetAP2) for further investigation.