Characterization of counterfeit artesunate antimalarial tablets from southeast Asia

Title
Characterization of counterfeit artesunate antimalarial tablets from southeast Asia
Authors
Hall, KA; Newton, PN; Green, MD; De Veij, M; Vandenabeele, P; Pizzanelli, D; Mayxay, M; Dondorp, A; Fernandez, FM
Keywords
TANDEM MASS-SPECTROMETRY; ELECTROSPRAY-IONIZATION; PHARMACEUTICAL ANALYSIS; DIETHYLENE GLYCOL; MALARIA; DRUGS; MEDICATION; EPIDEMIC; MURDER; TIME
Issue Date
2006
Publisher
AM J TROP MED HYG
Citation
Am. J. Trop. Med. Hyg.;NOV;2006;75;5
Abstract
In southeast Asia, the widespread high prevalence of counterfeits tablets of the vital antimalarial artesunate is of great public health concern. To assess the seriousness of this problem, we quantified the amount of active ingredient present in artesunate tablets by liquid chromatography coupled to mass spectrometry. This method, in conjunction with analysis of the packaging, classified tablets as genuine, substandard, or fake and validated results of the colorimetric Fast Red TR test. Eight (35%) of 23 fake artesunate samples contained the wrong active ingredients, which were identified as different erythromycins and paracetamol. Raman spectroscopy identified calcium carbonate as an excipient in 9 (39%) of 23 fake samples. Multivariate unsupervised pattern recognition results indicated two major clusters of artesunate counterfeits, those with counterfeit foil stickers and containing calcium carbonate, erythromycin, and paracetamol, and those with counterfeit holograms and containing starch but without evidence of erythromycin or paracetamol.
URI
http://hdl.handle.net/11267/2365
ISSN
0002-9637
Appears in Collections:
5.Mahosot Hospital > Journal articles
Files in This Item:

qrcode

Items in LAOSpace are protected by copyright, with all rights reserved, unless otherwise indicated.