Urine Antibiotic Activity in Patients Presenting to Hospitals in Laos: Implications for Worsening Antibiotic Resistance

Title
Urine Antibiotic Activity in Patients Presenting to Hospitals in Laos: Implications for Worsening Antibiotic Resistance
Authors
Khennavong, M; Davone, V; Vongsouvath, M; Phetsouvanh, R; Silisouk, J; Rattana, O; Mayxay, M; Castonguay-Vanier, J; Moore, CE; Strobel, M; Newton, PN
Keywords
ANTIMICROBIAL RESISTANCE; ANTIBACTERIAL ACTIVITY; DEVELOPING-COUNTRIES; SELF-MEDICATION; BACTERIAL-RESISTANCE; TRACT INFECTIONS; CHILDREN; BLADDER; AGENTS; BLOOD
Issue Date
2011
Publisher
AM J TROP MED HYG
Citation
Am. J. Trop. Med. Hyg.;AUG;2011;85;2
Abstract
Widespread use of antibiotics may be important in the spread of antimicrobial resistance. We estimated the proportion of Lao in- and outpatients who had taken antibiotics before medical consultation by detecting antibiotic activity in their urine added to lawns of Bacillus stearothermophilus, Escherichia coli, and Streptococcus pyogenes. In the retrospective (N = 2,058) and prospective studies (N =1,153), 49.7% (95% confidence interval [CI] = 47.4-52.0) and 36.2% (95% CI = 33.4-38.9), respectively, of Vientiane patients had urinary antibiotic activity detected. The highest frequency of estimated antibiotic pre-treatment was found in patients recruited with suspected central nervous system infections and community-acquired septicemia (both 56.8%). In Vientiane, children had a higher frequency of estimated antibiotic pre-treatment than adults (60.0% versus 46.5%; P < 0.001). Antibiotic use based on patients histories was significantly less frequent than when estimated from urinary antibiotic activity (P < 0.0001).
URI
http://hdl.handle.net/11267/2373
ISSN
0002-9637
Appears in Collections:
5.Mahosot Hospital > Journal articles
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