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Title: An expanded taxonomy of hepatitis C virus genotype 6: Characterization of 22 new full-length viral genomes
Authors: Li, CH; Barnes, E; Newton, PN; Fu, YS; Vongsouvath, M; Klenerman, P; Okamoto, H; Abe, K; Pybus, OG; Lu, L
Keywords: VOLUNTEER BLOOD-DONORS; HO-CHI-MINH; HIGH PREVALENCE; RISK-FACTORS; EAST-ASIA; HCV; THAILAND; INFECTION; SEQUENCES; VARIANTS
Issue Date: 2015
Publisher: VIROLOGY
Citation: Virology;FEB;2015;476;
Abstract: We characterized the full-length genomes of 22 hepatitis C virus genotype 6 (HCV-6) isolates: 10 from Vietnam (classified into subtypes 6e, 6h, 6p, 6r, 6s, and 6u), one from China (confirmed as a new subtype 6xd), and 11 from the Lao PDR (representing a new subtype 6xe plus eight novel variants). With these 22 new genomes, HCV-6 now has a diverse and extended taxonomic structure, comprised of 28 assigned subtypes (denoted 6a-6xe) and 27 unassigned lineages, all of which have been represented by full-length genomes. Our phylogenetic analyses also included many partially-sequenced novel variants of HCV-6 from Lao PDR. This revealed that Lao HCV isolates are genetically very diverse and are phylogenetically distributed in multiple lineages within genotype 6. Our results suggest that HCV-6 has been maintained in Laos, a landlocked country, since the common ancestor of genotype 6 and indicates historical dispersal of HCV-6 across Southeast Asia. (C) 2014 Elsevier Inc. All rights reserved.
URI: http://hdl.handle.net/11267/2376
ISSN: 0042-6822

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