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Title: An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos)
Authors: Mayxay, M; Thongpraseuth, V; Khanthavong, M; Lindegardh, N; Barends, M; Keola, S; Pongvongsa, T; Phompida, S; Phetsouvanh, R; Stepniewska, K; White, NJ; Newton, PN
Keywords: ARTEMETHER-LUMEFANTRINE; SULFADOXINE-PYRIMETHAMINE; THERAPEUTIC-EFFICACY; CHLOROQUINE; THAILAND; BENFLUMETOL; COMBINATION; PROVINCE; VIETNAM; MARKERS
Issue Date: 2006
Publisher: TROP MED INT HEALTH
Citation: Trop. Med. Int. Health;AUG;2006;11;8
Abstract: OBJECTIVE To determine the efficacy and safety of oral dihydroartemisinin-piperaquine (DP, Artekin(TM)) in the treatment of uncomplicated Plasmodium falciparum malaria in southern Laos. METHODS An open, randomized clinical trial of oral artesunate-mefloquine (AM) vs. DP in 220 patients with acute uncomplicated falciparum malaria in Savannakhet Province, Laos. CONCLUSION The 42-day cure rates (95% CI), as determined by survival analysis and adjusted for reinfection, were excellent and similar for the two groups [99 (94-100)% and 100 (100-100)% for AM and DP, respectively]. The median (range) fever and parasite clearance times for the AM and DP groups were also similar [20 (4-63) h and 2 (1-4) days vs. 20 (7-57) and 2 (1-4) days, logrank P = 0.4 and 0.17, respectively]. There were more patients with at least one potential side effect following treatment in the AM group when compared with the DP group [64/110 (58%) vs. 48/110 (44%), respectively, P = 0.031].
URI: http://hdl.handle.net/11267/2393
ISSN: 1360-2276

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