In Vivo Parasitological Measures of Artemisinin Susceptibility

Title
In Vivo Parasitological Measures of Artemisinin Susceptibility
Authors
Nair, S; Nkhoma, S; Nosten, F; Mayxay, M; French, N; Whitworth, J; Anderson, T
Keywords
PLASMODIUM-FALCIPARUM MALARIA; ARTESUNATE-MEFLOQUINE COMBINATION; ANTIMALARIAL-DRUGS; PHARMACODYNAMIC PROPERTIES; PARASITE CLEARANCE; RESISTANT MALARIA; THAILAND; EFFICACY; CAMBODIA; BORDER
Issue Date
2010
Publisher
J INFECT DIS
Citation
J. Infect. Dis.;15-Feb;2010;201;4
Abstract
Parasite clearance data from 18,699 patients with falciparum malaria treated with an artemisinin derivative in areas of low (n = 14,539), moderate (n = 2077), and high (n = 2083) levels of malaria transmission across the world were analyzed to determine the factors that affect clearance rates and identify a simple in vivo screening measure for artemisinin resistance. The main factor affecting parasite clearance time was parasite density on admission. Clearance rates were faster in high-transmission settings and with more effective partner drugs in artemisinin-based combination treatments (ACTs). The result of the malaria blood smear on day 3 (72 h) was a good predictor of subsequent treatment failure and provides a simple screening measure for artemisinin resistance. Artemisinin resistance is highly unlikely if the proportion of patients with parasite densities of <100,000 parasites/mu L given the currently recommended 3-day ACT who have a positive smear result on day 3 is <3%; that is, for n patients the observed number with a positive smear result on day 3 does not exceed. (n + 60)/24.
URI
http://hdl.handle.net/11267/2403
ISSN
0022-1899
Appears in Collections:
5.Mahosot Hospital > Journal articles
Files in This Item:

qrcode

Items in LAOSpace are protected by copyright, with all rights reserved, unless otherwise indicated.