Sennetsu Neorickettsiosis: A Probable Fish-Borne Cause of Fever Rediscovered in Laos

Title
Sennetsu Neorickettsiosis: A Probable Fish-Borne Cause of Fever Rediscovered in Laos
Authors
Paris, DH; Blacksell, SD; Newton, PN; Day, NPJ
Keywords
EHRLICHIA-SENNETSU; INFECTIONS; EPIDEMIOLOGY; TREMATODES; SEQUENCE; DISEASES; AGENT; PDR
Issue Date
2009
Publisher
AM J TROP MED HYG
Citation
Am. J. Trop. Med. Hyg.;AUG;2009;81;2
Abstract
Neorickettsia sennetsu has been described from Japan and Malaysia. causing a largely forgotten infectious mononucleosis-like disease. Because it is believed to be contracted from eating raw fish, frequently consumed in the Lao PDR, we looked for evidence of N. sennetsu among Lao patients and fish. A buffy coat from 1 of 91 patients with undifferentiated fever was positive by 16S rRNA amplification and sequencing, and real-time polymerase chain reactions (PCR) targeting two N. sennetsu genes. Lao blood donors and patients with fever, hepatitis, or jaundice (N = 1,132) had a high prevalence (17%) Of immunofluorescence assay IgG anti-N. sennetsu antibodies compared with 4% and 0% from febrile patients (N = 848) in Thailand and Malaysia, respectively. We found N. sennetsu DNA by PCR. for the first time, in a fish (Anabas testudineus). These data suggest that sennetsu may he ail under-recognized cause of fever and are consistent with the hypothesis that it may be contracted from eating raw fish.
URI
http://hdl.handle.net/11267/2413
ISSN
0002-9637
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5.Mahosot Hospital > Journal articles
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