A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos

Title
A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos
Authors
Phongmany, S; Phetsouvanh, R; Sisouphone, S; Darasavath, C; Vongphachane, P; Rattanavong, O; Mayxay, M; Ramsay, AC; Blacksell, SD; Thammavong, C; Syhavong, B; White, NJ; Newton, PN
Keywords
SALMONELLA-TYPHI; RESISTANT SALMONELLA; ENTERIC FEVER; CIPROFLOXACIN; CHILDREN; FLUOROQUINOLONES; EFFICACY; GROWTH
Issue Date
2005
Publisher
T ROY SOC TROP MED H
Citation
Trans. Roy. Soc. Trop. Med. Hyg.;JUN;2005;99;6
Abstract
We conducted a randomized open trial of oral chloramphenicol (50 mg/kg/day in four divided doses for 14 days) versus ofloxacin (15 mg/kg/day in two divided doses for 3 days) in 50 adults with culture-confirmed uncomplicated typhoid fever in Vientiane, Laos. Patients had been ill for a median (range) of 8 (2-30) days. All Salmonella enterica serotype typhi isolates were nalidixic acid-sensitive, four (8%) were chloramphenicol-resistant and three (6%) were multidrug-resistant. Median (range) fever clearance times were 90 (24-224) hours in the chloramphenicol group and 54 (6-93) hours in the ofloxacin group (P< 0.001). One patient in the chloramphenicol group developed an ileal perforation. Three days ofloxacin was more effective than 14 days chloramphenicol for the in-patient treatment of typhoid fever, irrespective of antibiotic susceptibility, and was of similar cost. © 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/11267/2425
ISSN
0035-9203
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5.Mahosot Hospital > Journal articles
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