Detecting counterfeit antimalarial tablets by near-infrared spectroscopy

Title
Detecting counterfeit antimalarial tablets by near-infrared spectroscopy
Authors
Sengaloundeth, S; Green, MD; Fernandez, FM; Manolin, O; Phommavong, K; Insixiengmay, V; Hampton, CY; Nyadong, L; Mildenhall, DC; Hostetler, D; Khounsaknalath, L; Vongsack, L; Phompida, S; Vanisaveth, V; Syhakhang, L; Newton, PN
Keywords
SOUTHEAST-ASIA; RAMAN-SPECTROSCOPY; FAKE ARTESUNATE; IDENTIFICATION
Issue Date
2008
Publisher
J PHARMACEUT BIOMED
Citation
J. Pharm. Biomed. Anal.;04-Nov;2008;48;3
Abstract
Counterfeit antimalarial drugs are found in many developing countries, but it is challenging to differentiate between genuine and fakes due to their increasing sophistication. Near-infrared spectroscopy (NIRS) is a powerful tool in pharmaceutical forensics, and we tested this technique for discriminating between counterfeit and genuine artesunate antimalarial tablets. Using NIRS, we found that artesunate tablets could be identified as genuine or counterfeit with high accuracy. Multivariate classification models indicated that this discriminatory ability was based, at least partly, on the presence or absence of spectral signatures related to artesunate. This technique can be field-portable and requires little training after calibrations are developed, thus showing great promise for rapid and accurate fake detection. Published by Elsevier B.V.
URI
http://hdl.handle.net/11267/2442
ISSN
0731-7085
Appears in Collections:
5.Mahosot Hospital > Journal articles
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