Characterization of nullYaa Chudnull Medicine on the Thailand-Myanmar Border: Selecting for Drug-resistant Malaria and Threatening Public Health

Title
Characterization of nullYaa Chudnull Medicine on the Thailand-Myanmar Border: Selecting for Drug-resistant Malaria and Threatening Public Health
Authors
Soukhathammavong, P; Sayasone, S; Harimanana, AN; Akkhavong, A; Thammasack, S; Phoumindr, N; Choumlivong, K; Choumlivong, K; Keoluangkhot, V; Phongmany, S; Akkhavong, K; Hatz, C; Strobel, M; Odermatt, P
Keywords
ANTIMALARIAL-DRUGS; FALCIPARUM-MALARIA; DEVELOPING-COUNTRIES; ARTESUNATE; COUNTERFEIT; COMBINATION; QUALITY; KENYA
Issue Date
2008
Publisher
AM J TROP MED HYG
Citation
Am. J. Trop. Med. Hyg.;NOV;2008;79;5
Abstract
Multidrug-resistant plasmodium falciparum malaria is a severe public health problem on the Thailand-Myanmar border. Many villagers buy packets of 4-5 mixed medicines (nullyaa chudnull) from shops without medical assessment as their first-line malaria treatment. In 2000-2001 a local researcher purchased 50 yaa chud from 44 shops around Mae Sot, Thailand and Myawaddy, Myanmar (Burma), for his wife who was said to be pregnant with fever and drowsiness. The tablets/capsules were provisionally identified by appearance and active ingredients determined in a subset by using mass and atomic spectrometry. The most frequently detected active ingredients were acetaminophen (22%), chlorpheniramine (13.4%), chloroquine (12.6%), tetracycline/doxycycline (11.4%), and quinine (5.1%). Only seven bags contained potentially curative medicine for malaria. A total of 82% of the bags contained medicines contraindicated in pregnancy. Inappropriate, ineffective antimalarial drugs on the Thailand-Myanmar border are likely to increase malaria morbidity, mortality and health costs and engender the emergence and spread of antimalarial drug resistance.
URI
http://hdl.handle.net/11267/2448
ISSN
0002-9637
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5.Mahosot Hospital > Journal articles
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