Assessment of hand-held Raman instrumentation for in situ screening for potentially counterfeit artesunate antimalarial tablets by FT-Raman spectroscopy and direct ionization mass spectrometry

Title
Assessment of hand-held Raman instrumentation for in situ screening for potentially counterfeit artesunate antimalarial tablets by FT-Raman spectroscopy and direct ionization mass spectrometry
Authors
Syhavong, B; Rasachack, B; Smythe, L; Rolain, JM; Roque-Afonso, AM; Jenjaroen, K; Soukkhaserm, V; Phongmany, S; Phetsouvanh, R; Soukkhaserm, S; Thammavong, T; Mayxay, M; Blacksell, SD; Barnes, E; Parola, P; Dussaix, E; Raoult, D; Humphreys, I; Klenerman, P; White, NJ; Newton, PN
Keywords
FAKE ARTESUNATE; SOUTHEAST-ASIA; DRUGS
Issue Date
2008
Publisher
ANAL CHIM ACTA
Citation
Anal. Chim. Acta;15-Aug;2008;623;2
Abstract
Pharmaceutical counterfeiting has become a significant public health problem worldwide and new, rapid, user-friendly, reliable and inexpensive methods for drug quality screening are needed. This work illustrates the chemical characterization of genuine and fake artesunate antimalarial tablets by portable Raman spectroscopy and validation by FT-Raman spectroscopy and ambient mass spectrometry. The applicability of a compact and robust portable Raman spectrometer (TruScan (TM)) for the in situ chemical identification of counterfeit tablets is reported. (C) 2008 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/11267/2454
ISSN
0003-2670
Appears in Collections:
5.Mahosot Hospital > Journal articles
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