Evaluation of the Standard Diagnostics Leptospira IgM ELISA for diagnosis of acute leptospirosis in Lao PDR

Title
Evaluation of the Standard Diagnostics Leptospira IgM ELISA for diagnosis of acute leptospirosis in Lao PDR
Authors
Tanganuchitcharnchai, A; Smythe, L; Dohnt, M; Hartskeerl, R; Vongsouvath, M; Davong, V; Lattana, O; Newton, PN; Blacksell, SD
Keywords
ASSAYS
Issue Date
2012
Publisher
T ROY SOC TROP MED H
Citation
Trans. Roy. Soc. Trop. Med. Hyg.;SEP;2012;106;9
Abstract
The diagnostic utility of the Standard Diagnostics Leptospira IgM ELISA for detection of acute leptospirosis was assessed in febrile adults admitted in Vientiane, Laos. Using the cut-off suggested by the manufacturer [optical density (OD) >= 0.75], the assay demonstrated limited diagnostic capacity with a sensitivity of 95% and a specificity of 41% compared with the Leptospira microscopic agglutination test, which is the serological gold standard. However, re-evaluation of the diagnostic cut-off to an OD of 1.7 demonstrated improved diagnostic accuracy overall (sensitivity 70%; specificity 78%). (c) 2012 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/11267/2459
ISSN
0035-9203
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5.Mahosot Hospital > Journal articles
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