Rourinoside and rouremin, antimalarial constituents from Rourea minor

Title
Rourinoside and rouremin, antimalarial constituents from Rourea minor
Authors
He, ZD; Ma, CY; Tan, GT; Sydara, K; Tamez, P; Southavong, B; Bouamanivong, S; Soejarto, DD; Pezzuto, JM; Fong, HHS; Zhang, HJ
Keywords
RHAPHIDOPHORA-DECURSIVA; PHORMIDIUM-TENUE; BRUCEA-JAVANICA; PLANTS; CYANOBACTERIUM; GLYCOLIPIDS; NEOLIGNAN; AGENTS
Issue Date
2006
Publisher
PHYTOCHEMISTRY
Citation
Phytochemistry;JUL;2006;67;13
Abstract
Bioassay-directed fractionation of the antimalarial active CHCl3 extract of the dried stems of Rourea minor (Gaertn.) Aubl. (Connaraceae) liana led to isolation of two glycosides, rourinoside (1) and rouremin (2), as well as five known compounds, 1-(26-hydroxyhexacosanoyl)-glycerol (3), 1-O-beta-D-glucopyranosyl-(2S,3R,4E-8Z)-2-N-(2'-hydroxypalmitoyl)-octadecasphinga-4,8-dienine, 9S,12S, 13S-trihydroxy-10E-octadecenoic acid, dihydrovomifoliol-9-beta-D-glucopyranoside, and beta-sitosterol glucoside. Compounds 1-3 showed weak in vitro activities against Plasmodium falciparum. Their structures and stereochemistry were elucidated by spectroscopic methods and selected enzyme hydrolysis. (c) 2006 Published by Elsevier Ltd.
URI
http://hdl.handle.net/11267/2589
ISSN
0031-9422
Appears in Collections:
2.Ministry of Health > Journal articles
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