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Title: Rourinoside and rouremin, antimalarial constituents from Rourea minor
Authors: He, ZD; Ma, CY; Tan, GT; Sydara, K; Tamez, P; Southavong, B; Bouamanivong, S; Soejarto, DD; Pezzuto, JM; Fong, HHS; Zhang, HJ
Keywords: RHAPHIDOPHORA-DECURSIVA; PHORMIDIUM-TENUE; BRUCEA-JAVANICA; PLANTS; CYANOBACTERIUM; GLYCOLIPIDS; NEOLIGNAN; AGENTS
Issue Date: 2006
Publisher: PHYTOCHEMISTRY
Citation: Phytochemistry;JUL;2006;67;13
Abstract: Bioassay-directed fractionation of the antimalarial active CHCl3 extract of the dried stems of Rourea minor (Gaertn.) Aubl. (Connaraceae) liana led to isolation of two glycosides, rourinoside (1) and rouremin (2), as well as five known compounds, 1-(26-hydroxyhexacosanoyl)-glycerol (3), 1-O-beta-D-glucopyranosyl-(2S,3R,4E-8Z)-2-N-(2'-hydroxypalmitoyl)-octadecasphinga-4,8-dienine, 9S,12S, 13S-trihydroxy-10E-octadecenoic acid, dihydrovomifoliol-9-beta-D-glucopyranoside, and beta-sitosterol glucoside. Compounds 1-3 showed weak in vitro activities against Plasmodium falciparum. Their structures and stereochemistry were elucidated by spectroscopic methods and selected enzyme hydrolysis. (c) 2006 Published by Elsevier Ltd.
URI: http://hdl.handle.net/11267/2589
ISSN: 0031-9422

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