Antimalarial constituents from Nauclea orientalis (L.) L.

Title
Antimalarial constituents from Nauclea orientalis (L.) L.
Authors
He, ZD; Ma, CY; Zhang, HJ; Tan, GT; Tamez, P; Sydara, K; Bouamanivong, S; Sothavong, B; Soejarto, DD; Pezzuto, JM; Fong, HHS
Keywords
RHAPHIDOPHORA-DECURSIVA; MONOTERPENE GLUCOSIDES; ALANGIUM-LAMARCKII; BIOSYNTHESIS; ALKALOIDS; AGENTS; PLANTS
Issue Date
2005
Publisher
CHEM BIODIVERS
Citation
Chem. Biodivers.;;2005;2;10
Abstract
Bioassay-guided fractionation of the antimalarial-active CHCl3 extract of the dried stem of Nauclea orientatis (L.) L. (Rubiaceae) has resulted in the isolation of two novel tetrahydro-beta-carboline monoterpene alkaloid glucosides, naucleaorine (=(16 alpha,17 beta)-3,14:15,20-tetradehydro-16-ethenyl-17-(beta-D-glueopyranosyloxyl- 19 alpha-methoxyoxayohimban-21-one; 1) and epimethoxynaucleaorine (2), as well as the known compounds, strictosidine lactam (= ( 15 beta, 16 alpha, 17 beta)-19,20-didehydro-16-ethenyl-17-(beta-D-glucopyranosyloxy)oxayohimban-21-one; 3), 3,4,5-trimethoxyphenol (4). 3 alpha-hydroxyurs-12-en-28-oic acid methyl ester (5). 3 alpha,23-dihydroxy-urs-12-en-28-oic acid (6), 3 alpha,19 alpha,23-trihydroxyurs-12-en-28-oic acid methyl ester (7). and oleanolic acid (8). Compounds 1, 2, 6, and 8 showed moderate in vitro activities against Plasmodium falciparum. Their structures and configurations were elucidated by spectrocopic methods including 1D- and 2D-NMR analyses.
URI
http://hdl.handle.net/11267/2595
ISSN
1612-1872
Appears in Collections:
2.Ministry of Health > Journal articles
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