Bioactive constituents from Asparagus cochinchinensis

Title
Bioactive constituents from Asparagus cochinchinensis
Authors
Zhang, HJ; Sydara, K; Tan, GT; Ma, CY; Southavong, B; Soejarto, DD; Pezzuto, JM; Fong, HHS
Keywords
NMR SPECTRAL INVESTIGATIONS; STEROIDAL SAPONINS; MEDICINAL-PLANTS; SAPOGENINS; YUCCA; RADIX
Issue Date
2004
Publisher
J NAT PROD
Citation
J. Nat. Prod.;FEB;2004;67;2
Abstract
Bioassay-directed fractionation of the dried roots of Asparagus cochinchinensis led to the isolation of a new spirostanol saponin, asparacoside (1), two new C-27 spirosteroids, asparacosins A (2) and B (3), a new acetylenic derivative, 3null-methoxyasparenydiol (4), and a new polyphenol, 3'-hydroxy-4'-methoxy-4'dehydroxynyasol (6), as well as five known phenolic compounds, asparenydiol (5), nyasol (7), 3null-methoxynyasol (8), 1,3-bis-di-p-hydroxyphenyl-4-penten-1-one (9), and trans-coniferyl alcohol (10). Compounds 1, 6, and 8 demonstrated moderate cytotoxicities in a panel comprised of KB, Col-2, LNCaP, Lu-1, and HUVEC cells, with IC50 values ranging from 4 to 12 mug/mL. The structures were determined by spectroscopic and chemical methods.
URI
http://hdl.handle.net/11267/2602
ISSN
0163-3864
Appears in Collections:
2.Ministry of Health > Journal articles
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