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Title: Distribution of the two forms of Plasmodium falciparum erythrocyte binding antigen-175 (eba-175) gene in Lao PDR
Authors: Dittrich, S; Schwobel, B; Jordan, S; Vanisaveth, V; Rattanaxay, P; Christophel, EM; Phompida, S; Jelinek, T
Keywords: LIGAND
Issue Date: 2003
Publisher: MALARIA J
Citation: Malar. J.;JUL;2003;2;
Abstract: Background: The erythrocyte binding antigen 175 (EBA-175) is a 175 kDa antigen of Plasmodium falciparum and plays a major role in erythrocyte recognition by the parasite. The antigen is also supposed to be partly responsible for the invasion of erythrocytes by merozoites. EBA-175 has been sequenced from the FCR-3 and CAMP strains of P. falciparum. The sequences were identical in most parts of the gene. Differences were apparent in a 423 bp segment in the FCR-3 strain, the F-Fragment, that is not found in the CAMP-strain and a 342 bp segment, the C-Fragment, which is present in the CAMP-strain but not in the FCR-3-strain. The aim of this study was to assess the distribution of the two EBA-175-alleles in the Lao PDR. Materials & Methods: Altogether, 240 blood-samples were collected in two areas of the country: Attapeu in the south and Lung Namtha in the north. Subsequently, the material was scanned for the F- and C-fragments. Results: In the whole study population, 52% carried the F- fragment, and 41% the C-fragment while seven percent of the patients were infected with at least two parasite strains and showed both alleles. Conclusion: Distribution of the alleles showed significant differences between the north and the south province. Reasons for this include possible importation of different parasite strains from neighbouring countries.
URI: http://hdl.handle.net/11267/2606
ISSN: 1475-2875

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